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Isner is always very predictable when it comes to first round matches. He opened 14 tournaments last season with a tie-break. That is his usual style but gets even 'worse' when he has no confidence. He takes less risk against his opponent's service until he find the winning rhythm and that, in turn, makes him much less dangerous. His serving is consistent. He played two matches last week with one tie-break. Matosevic is a a bit of a quirk but probably knows that no tricks will do against Isner. Only one first set in three head-to-head matches didn't finish in a tie-break. That was last season when Isner won in straight sets with only one break in the whole match. The Australian won a single break in those three matches. I don't he can count on winning breaks back, which means focus in own service games is the key.