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By watching both players in the first two rounds of Charleston I can easily conclude that Keys is playing at a much higher level. Lauren had more luck and she hasn't showed much of quality tennis, because she defeated bad Min in the first round, and catastrophic Bouchard in the second, who seems to be enjoying sabotaging herself and losing. Keys is very convincing on her serve, conditions here suit her and she should win by six or more games.
Regardles of the fact that these players know each other well, they are in a state of war when they get out on the court - which was best demonstrated by Keys in Eastbourne last year. I expect a similar outcome today as well, any other result would be surprising. Keys is superior in every part of the game and it will all depend on her and her interest, which is, based on her attitude in the previous two matches, at a very high level.